Humalog Mix 25 Cartridges 100 Units/mL


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Humalog Mix 25 cartridge is a premixed suspension that is usually prescribed along with long-acting type insulin. It combines two medications used to manage blood sugar levels and severe complications related to type 1 and type 2 diabetes mellitus.

Humalog Mix 25 100IU/ml Cartridge has a prolonged duration of action and a fast onset of action. Together, it ensures rapid and consistent control to manage blood glucose levels throughout the day.

A doctor or nurse should provide training on how to administer insulin in the form of injection properly. Managing your blood sugar levels is an essential part of diabetes management which can help you avoid any risks and complications such as eye damage, kidney damage, nerve problems, or loss of limbs.

25% insulin lispro is the active substance dissolved in water. It works faster than insulin produced by the body since it has had a molecular modification. Protamine sulfate makes up the other 75% of Humalog Mix 25 in the form of a suspension.

Humalog has many products including, KwikPens 200, Mix 25 KwikPens, vials and cartridges.

Your doctor or nurse will provide instruction on how to inject under the skin properly. It should be taken 15 minutes before starting your meal or within 20 minutes of creating your meal. Do not discontinue using insulin unless advised by your doctor.

Humalog Mix 25 should be used as part of a treatment program that includes a healthy diet, weight loss, and exercise program as advised by your doctor, allowing patients to live a more healthy life.



Additional information


Low, HIgh

Warnings and Precautions

Hypoglycemia or low blood sugar is the most common adverse effect experienced by insulin users. Blood glucose monitoring is recommended for all patients with diabetes (type 1, type 2, gestational and brittle). Uncorrected hypoglycemic or hyperglycemic reactions can cause loss of consciousness, coma, or even death. Information on how to recognize these symptoms is provided below.

Humalog Mix25 should be given within 15 minutes before a meal.

Humalog Mix25 is a white suspension and should be administered by subcutaneous injection only. Humalog Mix25 must not be administered intravenously.

Any change of insulin regimen should be made cautiously and only under medical supervision. Changes in purity, strength, brand (manufacturer), type (regular, NPH, etc.), species (beef, pork, beef-pork, human), and method of manufacture (recombinant DNA versus animal-source insulin) may result in the need for a change in dosage.

Mixing Humalog Mix25 with either animal insulins or insulin preparations produced by other manufacturers is not recommended.

Patients taking Humalog Mix25 may require a change in dosage from that used with other insulins. If an adjustment is needed, it may occur with the first dose or over several weeks. It is easy for patients to get confused between Humalog and Humulin (as they have similar names). Please be sure you are using the appropriate insulin that your doctor has recommended. 


It is essential to check your blood sugar levels regularly, keep track of your results and share them with your doctor so they can prescribe the correct dose for you.

Humalog Mix25 should be used 15 minutes before starting a meal and within 20 minutes of creating your meal.

Inject insulin as instructed by your doctor or nurse under the skin (subcutaneously). Injection sites include upper arms, buttocks, upper leg, and abdomen. Do not massage the area of injection after injecting.

To prevent hard lumps from developing at one site, rotate injection sites.

Do not change insulin type or brand unless advised by your doctor, as it may require a dosage modification.

Opened cartridges stay good at room temperature for up to four weeks.

Do not keep this medication in a freezer.

Humalog Mix25 should appear cloudy or milky after mixing well.

Always carry glucose tablets, candy, or a sugary drink if blood sugar levels drop too low.

Side Effects

Other significant side effects include allergic reactions at the site of injection. This can usually include swelling, redness, itching, and lumps (lipodystrophy) at the injection area.

Common side effects with Humalog Mix 25 100IU/ml Cartridge include hypoglycemia, injection site allergic reactions, lipodystrophy (pits or skin thickening at the injection site), itching, rashes, sweating, vomiting, headache, palpitations, and listlessness.

If you are experiencing any side effects, consult with your doctor.


Humalog Mix25 insulin contains 100 units/mL of Human Insulin Analogue. Humalog Mix25 includes a mix of insulin lispro injection (25%) and insulin lispro protamine suspension (75%).

The non-medicinal ingredients are: Humalog Mix25 contains glycerol, dibasic sodium phosphate, m-cresol, zinc (as ion), and water for injection. Hydrochloric acid or sodium hydroxide may be added to adjust pH. Humalog Mix25 also contains liquefied phenol, protamine sulfate, and zinc oxide.


Opened Humalog25 cartridges should be stored at room temperature for up to 4 weeks. Unopened medication should be refrigerated at 2°C–8°C. Cartridges maintain integrity at room temperature for up to 4 weeks.

Frequently Asked Questions

When should I take Humalog Mix25 Cartridge?

Take 15 minutes before each meal or 20 minutes before starting your meal.

Where should insulin be injected?

Inject below the skin (subcutaneously) of the abdomen for faster results. It can also be injected into the upper arm, thigh, or buttocks.

How do I inject insulin?

i) Wash your hands before injecting.
ii) Choose the site of injection
iii) Clean area of injection site
iv) Remove the needle cap
v) Unscrew needle and dispose of safely
vi) Pinch up a large area of skin
vii) Insert needle as instructed
viii) Press the knob
ix) Pull the needle out and apply pressure gently for a few seconds
x) Using the outer needle cap, unscrew the needle and dispose of it safely.

How to prepare Humalog Mix 25 100IU/ml Cartridge before injection?

Your insulin device should be rotated in the palm of your hands ten times and inverted 180 degrees 10 times before you re-suspend insulin until it appears milky or cloudy. Repeat until contents are mixed. Do not shake as this may lead to frothing, which can interfere with the correct dosage. Examine the cartridge/device frequently and do not use it if particles or clumps are present, giving a frosty appearance.

Do I need to prime my pen before use?

Yes, you will need to prime your injector pen. If not, you may get too little or too much insulin. For priming, turn the dose knob to 2 units. Hold the pen with the needle pointing up and tap the cartridge holder gently to collect any air bubbles at the top. Continue holding your pen with the needle pointing up and push the dose knob until it stops at zero in the dose window. Hold the dose knob in and slowly count to five. You should begin to see insulin at the needle tip.

What should I do if the dose knob is hard to push?

Pushing the dose knob slowly will make insulin easier to inject. If your needle is blocked, put a new need and prime your pen once again.

Which drugs may require an insulin dosage increase?

Medications that cause hyperglycemic activity (increase glucose levels) include corticosteroids, certain lipid-lowering drugs (i.e., niacin), oral contraceptives, thyroid replacement drugs, estrogens, isoniazid, phenothiazines, and corticosteroids.

Which drugs may require a decrease of insulin requirement?

Insulin requirements may need to be decreased in the presence of medications that lower blood sugar levels, such as oral antidiabetic agents, sulfa antibiotics, angiotensin II receptor blocking agents, inhibitors of pancreatic function (i.e., octreotide), certain antidepressants, beta-adrenergic blockers, angiotensin-converting-enzyme inhibitors.

Notify your doctor of any medications or supplements you are currently taking.

Is it safe to use while breastfeeding (lactation) or pregnancy?

Studies have shown that there are no adverse effects of insulin lispro during pregnancy or on the health of a fetus or baby. Insulin requirements may drop during the first trimester and increase during the second and third. Patients should consult their doctor if they are pregnant, considering pregnancy, or breastfeeding for specific instructions. It is essential to monitor blood sugar levels during pregnancy. For women who are breastfeeding, an adjustment to insulin dosage may be required.