Humalog Mix 25 KwikPens 100 Units


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Humalog Mix 25 KwikPens are lightweight, small pen that’s prefilled with mealtime insulin. It does need to be refrigerated after the first use, which means you can take it anywhere, and due to its small size, it’s easy to carry. They also are re-fillable through replacing the cartridges.

Once you start using Humalog Mix 25 KwikPens, it should be stored at room temperature, below 86°F (30°C), and must be used within ten days or be discarded, even if it still contains Humalog. For more information, please see the storage tab.

The Humalog Mix 25 Kwikpens (100IU/ml) is an insulin pen that contains a combination of two medications, insulin lispro (25%), which has a fast onset of action, and insulin lispro protamine (75%) that has a prolonged duration of action. Together, these two medicines ensure consistent and rapid sugar control throughout the day by facilitating the re-up take of sugar in muscle and fat cells and suppressing sugar production in the liver.

Insulin should be part of your diabetes treatment program advised by a doctor, combined with a healthy diet, exercise, and weight reduction.

The Humalog Mix25 KwikPen is usually prescribed alongside a long-acting type of insulin by doctors. It effectively manages blood sugar levels for type 1 and types two diabetes to avoid diabetes-related complications.

Humalog also makes different variations of the KwikPen, including the 100 units, 200 units, and the Junior Pen.

Additional information


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Warnings and Precautions

Notify your doctor if you currently have any liver, kidney, or heart problems before starting treatment.

Are you pregnant or thinking about becoming pregnant, or are you breastfeeding? The amount of insulin you need usually falls during the first three months of pregnancy and increases for the remaining six months. If you are breastfeeding, you may need to alter your insulin intake or diet. Ask your doctor for advice. See the pregnancy tab for more information. 

Do not stop taking medication unless instructed by your doctor.

Do not drive or operate heavy machinery if blood sugar levels are too high or too low unless suggested differently by your doctor.

Patients with liver or kidney disease should use it with caution. Consult your doctor as you may require a dose adjustment.


Your doctor or nurse should instruct you on how to administer your insulin correctly.

Humalog Mix 25 KwikPens are injected under the skin (subcutaneously). Inject in the abdomen for faster absorption. Insulin can also be injected into the skin of the upper legs and arms or buttocks. After injection, do not massage the area of injection.

It is taken 15 minutes before your meal or within 20 minutes of starting your meal.

It is essential to monitor blood sugar levels regularly and share results with your doctor to provide the correct dosage based on your individual needs.

Rotate injection sites to prevent hard lumps from forming at injection sites.

Low blood sugar or hypoglycemia may result when taken with other antidiabetic medicines, skipping or delaying meals, or consuming alcohol.

Carry a sugar source such as glucose tablets, candy, or sugary drinks to relieve hypoglycemia immediately.

Available insulin vials or cartridges can be stored at room temperature for up to 4 weeks. Unopened vials should refrigerate at 2°C–8°C.

Similar usage instructions should be considered when using Humalog vials.

How to inject insulin?

1. Wash hands before injecting.
2. Choose an area for injection
3. Clea area of injection
4. Stabilise the skin by pinching it
5. Insert the needle
6. Press the knob
7. Pull the needle out and apply gentle pressure over the site of injection for a few seconds
8. Using the outer needle cap, unscrew the needle and dispose of it as instructed by the pharmacist

Preparation of Humalog Mix 25 KwikPens

You should rotate the Humalog Mix 25 Kwikpen in the palm of your hand ten times and inverted 180 degrees ten times before use to re-suspend the insulin until it appears cloudy or milky. Do not use until the contents are mixed. Do not shake the device too hard as this may cause frothing can interfere with dose-measuring. Examine the device for any particles floating inside, giving a frosted appearance.

How to prime your Humalog Mix 25 KwikPens

Priming your pen is required. If this is not done correctly, you may receive too much or too little insulin. To do this, turn the dial two units. Hold your pen with the needle pointing up. Tap the cartridge holder to get air bubbles to the top. Push the dose knob until the dosage window stops at “0”. Hold dose knob and count to five. You should then see the insulin at the tip of the needle.

What to do if the dose knob becomes stiff or rigid to push?

Pushing the dose knob on the pen slowly will make it easier to inject. Put on a new needle and prime the pen if the needle is blocked.

Side Effects

An essential part of managing your diabetes is through the management of blood glucose levels. If you control your blood sugar levels, you can avoid serious complications such as nerve damage, eye damage, kidney damage, and loss of limbs.

Managing blood glucose levels is an essential part of managing diabetes. If you can control the level, you will reduce the risk of getting any severe complications of diabetes such as kidney damage, eye damage, nerve problems, and loss of limbs. Taking this medicine regularly and proper diet and exercise will help you live everyday, healthy life.

As with most insulin medications, the most common side effect is low blood sugar levels, hypoglycemia. This can be avoided by injecting the correct dosage, having regular meals, and monitoring blood sugar levels regularly. Avoid excessive alcohol consumption as this can also lower blood sugar levels.

Allergic reactions at the injection site such as redness, hard lumps (lipodystrophy), and swelling are also common. Some have reported itching and rashes while taking insulin.

Common side effects of Humalog Mix 25 KwikPens include low blood sugar levels (hypoglycemia). Symptoms of hypoglycemia may include confusion, headache, palpitations, shakiness, increased heartbeat, anxiety, blurred vision, headache, vomiting, sweating, mood changes, hunger, irritability, and listlessness.

Other common side effects include allergic reactions at the injection site, lipodystrophy (skin thickening or pits at the injection site), rashes, and itching.

Drug Interactions

The following drugs may require an increase of insulin: Corticosteroids, Isoniazid, Estrogens, Oral contraceptives, Certain lipid-lowering drugs (i.e., niacin), Phenothiazines, and Thyroid replacement therapy.

The following drugs can decrease insulin requirements: Angiotensin-converting-enzyme inhibitors, oral antidiabetic agents, salicylates, angiotensin II receptor blocking agents, and certain antidepressants (monoamine oxidase inhibitors), beta-adrenergic blockers, inhibitors of pancreatic function, beta-adrenergic blockers may mask symptoms of hypoglycemia for some, sulfa antibiotics and alcohol.

Most side effects do not require medical attention and disappear as your body adjusts to the medication.

It is essential to advise your doctor if you are experiencing any side effects of adjusting your dosage and treatment.


Let your doctor know if you are pregnant or breastfeeding, as the dosage may be adjusted.

Humalog Mix 25 KwikPens are generally safe to take during pregnancy. Animal studies have shown that there are little to no side effects to developing babies. However, there have been limited human studies. Insulin requirements usually fall during the first trimester and increase during the second and third trimesters. Inform your doctor if you are pregnant.

It is also safe during breastfeeding. Human studies have shown that the medication does not pass through breast milk in a significant amount that would be harmful to the baby. During breastfeeding, your doctor may recommend adjusting dosage requirements, diet, or both.


Before the first use, store your Humalog Mix 25 KwikPens in a refrigerator (2° C – 8° C). Do not freeze.

Keep your Humalog Mix 25 KwikPens in use at room temperature (below 30° C) and discard it after 28 days. Please do not put it near heat or in the sun. Do not keep the KwikPen that you are using in the fridge. The KwikPen should not be stored with the needle attached.

Keep out of sight and reach of children.

Do not use this medicine after the expiry date stated on the label and the carton. The expiry date refers to the last day of that month.

Do not use this medicine if you notice clumps of material are present or if solid white particles stick to the bottom or wall of the cartridge, giving it a frosted appearance. Check each time you inject yourself.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medications no longer required. These measures will help to protect the environment.