Humalog Mix50 Cartridges (100 Units/mL)


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Humalog Mix50 Cartridges contains a combination of 50% insulin lispro (fast-acting insulin) and 50% insulin lispro protamine (longer-acting insulin). Humalog Mix50 has a shorter duration of activity and takes effect more rapidly when compared to regular insulin.

They also have a wide variety of mixtures, including  KwikPens 200 and many available cartridges in different formulas to refill your pens!

Insulin is a hormone produced by the pancreas, which is a large gland located near the stomach. Insulin is used to regulate blood glucose levels. Diabetes occurs when the body seizes to create insulin naturally.

Together, they ensure consistent and rapid control of blood sugar levels by facilitating glucose re-up take in the muscle and fat cells and suppressing sugar production in the liver.

Humalog Mix50 Cartridges contains a combination of two medications. Insulin lispro has a fast onset of action, and insulin lispro protamine has a prolonged duration of action. Together, they provide rapid-acting insulin control to manage blood sugar levels in addition to consistent delivery throughout the day.

Managing sugar levels is extremely important for people with diabetes to avoid complications associated with diabetes, such as eye damage, kidney damage, nerve problems, and loss of limbs. Typically this diabetes medication is used as part of a treatment program. When accompanied by an improved lifestyle of exercise and diet, this diabetes medication can help you live an everyday healthy life.

Doctors typically prescribe Humalog Mix50 Cartridges with long-acting insulin or other diabetes medications. Your doctor should provide instructions on proper usage and dosage according to your individualized needs.

The Humalog Mix50 formula is also available through injectable KwikPens.

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Warnings & Precautions

Humalog Mix 50 100IU/ml Cartridge should be used with caution for kidney or liver disease patients.

It is safe for women who are pregnant or breastfeeding. Human studies have shown that it does not pass through breast milk significantly and is not harmful to the baby. Your doctor may modify women who are pregnant or breastfeeding dosages.

Humalog Mix50 Cartridges are typically considered safe during pregnancy. Studies on animals have shown little to no side effects to the developing baby; however, these studies were limited.

Do not drink excessive alcohol, as this can lead to a drop in blood sugar levels.

Do not share insulin with others as this can lead to blood pathogens and severe infections.

Unmanaged diabetes can lead to severe problems, including blindness, kidney failure, strokes, poor circulation, and nerve damage. With proper diabetes treatment, these issues can be reduced or prevented.

Do not operate heavy machinery or drive if your blood sugar levels are too high or too low.

Ensure you are pre-filling your pen with the right cartridge. Humalog comes in different forms (ie, Humalog Mix25 KwikPens) and it can be easily mistaken for another product.


The rapid onset of activity requires Humalog Mix50 to be taken 15 minutes before starting your meal or within 20 minutes of creating your meal. The time to take your insulin may vary for each individual. The injection would be similar to that of a syringe and vial technique.

Like any insulin, the duration of Humalog Mix50 can depend on the dose, site injection, temperature, blood supply, and physical activity.

It would be best if you did not stop taking this medication unless otherwise instructed by your doctor.

As with any insulin, you should monitor your blood sugar levels regularly using a glucose monitor. Please keep track of results and share them with your doctor.

For faster absorption, injected below the skin of the abdomen. Other injection sites include the upper arm, thighs, or buttocks. Do not massage the area after injection.

Rotate injection sites to avoid lumps or skin irritations. Do not inject into chunks. Consult your doctor if you are unsure about injection sites.

Do not change to another brand or type of insulin unless advised by your doctor, as a modification to dosages may be required.

Carry glucose tablets, candy, or a sugary drink if you experience hypoglycemia (low blood sugar) which can happen from skipping a meal, consuming alcohol, or taking other anti-diabetic medication.

Your diabetes treatment should also include a balanced diet, regular exercise, and taking medication as prescribed by your doctor.

Injection Site

The injection site should be rotated to prevent skin changes such as lumps under the skin. The insulin may not work very well if you inject it into a lumpy area. Contact your doctor if you are currently injecting into a lumpy area before injecting a different location. Your doctor may tell you to check your blood sugar more closely and adjust your insulin or other antidiabetic medication doses.

Side Effects

The most common side effect of this medication is low blood sugar levels, also known as hypoglycemia. It’s essential to inject the correct dosage, monitor blood sugar levels, and have regular meals to avoid this complication.

You may experience itching or a rash while taking it. An allergic reaction at the injection site includes swelling, redness, or hard lumps (lipodystrophy).

Most side effects do not require immediate medical attention and go away as the body adjusts to the medication; however, you should contact your doctor if issues persist.


Humalog Mix50 Cartridges insulin contains 100 units/mL of Human Insulin Analogue. These cartridges includes a mix of insulin lispro injection (50%) and insulin lispro protamine suspension (50%).

The non-medicinal ingredients are: Humalog Mix50 contains glycerol, dibasic sodium phosphate, m-cresol, zinc (as ion), and water for injection. Hydrochloric acid or sodium hydroxide may be added to adjust pH. Humalog Mix50 also contains liquefied phenol, protamine sulfate, and zinc oxide.

Drug Interactions

Insulin requirements may increase if you take other drugs with hyperglycemic activity, such as oral contraceptives (for example, birth control pills, injections, and patches), corticosteroids, or thyroid replacement therapy. Insulin requirements may be decreased in the presence of agents such as oral antidiabetic agents, salicylates (aspirin), sulfa antibiotics, certain antidepressants (monoamine oxidase inhibitors), beta-blockers, alcohol, ACE inhibitors, and angiotensin II receptor blockers. Always discuss any medications you are taking with your doctor.

The use of thiazolidinediones (such as rosiglitazone and pioglitazone), alone or in combination with other antidiabetic agents (including insulin), has been associated with heart failure and swelling of the lower extremities. Be sure to get in touch with your physician immediately if you develop symptoms of shortness of breath, fatigue, exercise intolerance, or swelling of the lower extremities while you are on these agents.

Be sure to mention to your doctor of any drugs you are currently taking. This includes weight loss medications, such as Ozempic. It is essential your doctor knows all medications and supplements you are taking, as they would be able to properly prescribe you with the correct medication.


Hypoglycemia (too little glucose in the blood) is one of the most frequent adverse events experienced by insulin users. It can be brought about by:

1. Missing or delaying meals

2. Taking too much insulin

3. Exercising or working more than usual

4. An infection or illness (especially with diarrhea or vomiting)

5. A change in the body’s need for insulin

6. Diseases of the adrenal, pituitary, or thyroid gland, or progression of kidney or liver disease

7. Interactions with other drugs that lower blood glucose, such as oral hypoglycemics, salicylates, sulfa antibiotics, and certain antidepressants

8. Consumption of alcoholic beverages


Humalog Mix50 can be used in pregnancy if clinically indicated. Data on a large number of exposed pregnancies do not display any adverse effect of Humalog Mix50 on pregnancy or the health of the fetus/newborn.

Reasonable control of diabetes is essential for you and your unborn baby. Pregnancy may make managing your diabetes more difficult. Consult your doctor if you are planning to have a baby, are pregnant, or are nursing a baby.


Before the first use, store your Humalog Mix50 Cartridges in a refrigerator (2° C – 8° C). Do not freeze.

Keep your cartridge in use at room temperature (below 30° C) and discard it after 28 days. Please do not put it near heat or in the sun. Do not keep your pen or the cartridges you are using in the fridge. The pen with the inserted cartridge should not be stored with the needle attached.

Keep out of sight and reach of children.

Do not use this medicine after the expiry date stated on the label and the carton. The expiry date refers to the last day of that month.

Do not use this medicine if you notice clumps of material are present or if solid white particles stick to the bottom or wall of the cartridge, giving it a frosted appearance. Check each time you inject yourself.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medications no longer required. These measures will help to protect the environment.